Truvada is an antiretroviral drug used in the management of HIV. While the drug has seen a high level of success, its manufacturer, Gilead Science Inc., has recently begun to face lawsuits from users who have suffered serious damages from taking the medication.
The issue stems from the company’s use of a medicinal component known as tenofovir disoproxil fumarate (TDF). Studies have shown that TDF is correlated with bone density loss, which, in turn, is tied into kidney-related issues.
And Gilead Sciences Inc. has been fully aware of this for years. The company even went so far as to stifle an alternative form of the medication that would have been much safer for users.
But there is hope.
Our trustworthy New Jersey Truvada lawsuit lawyers at Onder Law Firm are ready to provide the quality legal counseling you need to hold this pharmaceutical company responsible. Contact us right now at (314) 310-7924 for a FREE, no-obligation consultation.
Truvada is a once-a-day tablet that was first approved by the U.S. Food and Drug Administration (FDA) in 2004 for the management of HIV. In 2012, the FDA approved it as a pre-exposure prophylaxis (PrEP) for people who do not have the virus but who are at high risk of infection, including those who are in a serodiscordant relationship.
What makes Truvada so effective is two medicinal components known as emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF). These components are known as nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs work by preventing a particular HIV enzyme from multiplying, thus reducing the amount of HIV-infected cells within the body.
The issue at hand is that studies have linked TDF with significant loss of bone mineral density. Over time, bone demineralization can lead to brittle bones and even osteoporosis. When coupled with a variety of other factors, including genetics and unhealthy lifestyle habits, the use of Truvada can lead to an increased risk of bone fractures or breaks.
As Truvada causes demineralization, the kidneys must filter out this excess of calcium and other minerals. This can be problematic for a user’s kidneys and ultimately lead to health-related complications including kidney disease.
Clinical studies showed that Gilead Science was fully aware of these dangers and yet ignored the warnings. To make matters worse, the company had been in the process of creating an alternative component known as tenofovir alafenamide fumarate (TAF).
TAF-based medicines are just as effective as TDF-based medications but do not require such a large dose and thus do not pose the same risks to users.
Bones are made primarily from collagen protein, calcium phosphate, and calcium carbonate. Old bone is broken down in a process known as resorption, while new bone is created in a process known as formation.
Truvada affects these processes, leading to bone breaking down faster than it can be created. When this happens, bone loss begins to occur. Individuals affected by HIV already face an increased risk of bone loss. Research has shown that bone loss occurs at a higher rate in those with HIV in comparison to those without it.
Factors that can affect bone loss rate include:
While Truvada is one of the more recognized HIV Medications medications on the market, there are several additional drugs which are believed to cause similar effects. Individuals should take note of the following drugs which contain TDF:
If preventative measures are not taken, then bone-related health issues can arise, including:
Oftentimes, users may not even be aware they are suffering from bone demineralization until they suffer an unexpected break or fracture. Areas that are prone to fractures or breaks include:
If you have been taking Truvada, talk to your doctor immediately to learn more about what tests can be conducted to better understand whether or not you have been affected by bone mineral density loss and to what degree.
You should not have to suffer from bone-related health issues after taking Truvada. Contact the New Jersey Truvada lawsuit attorneys of Onder Law Firm at (314) 310-7924 to schedule your FREE consultation.
While individuals with HIV already face an increased risk of chronic kidney disease and acute renal failure, research done at the San Francisco VA Medical Center (SFVAMC) and the University of California San Francisco (UCSF) revealed that the risk of developing kidney issues grew by 33 percent each year when exposed to TDF.
While bone demineralization is certainly a cause for concern, kidney disease can be catastrophic to a Truvada user’s quality of life. If kidney health issues are not resolved in time, they may ultimately lead to irreversible kidney failure.
When kidney damage caused by Truvada becomes significant, you may begin to suffer from chronic kidney disease (CKD). Sign and symptoms of CKD include:
If renal function falls below 25 percent then other health issues can arise including increased risk of a heart attack or stroke. Kidney failure is the last stage of CKD and typically requires dialysis and/or a kidney transplant.
Death is a very real possibility if CKD and kidney failure are not properly treated.
The State of New Jersey Department of Health website provides valuable insight into the rates and reported numbers of HIV/AIDS cases within the state.
As per estimates reported as of December 31, 2017:
Counties in the State of New Jersey which saw the highest rates of HIV positive infection or AIDS as of December 31, 2017 included:
The AIDSVu organization also provides statistics regarding HIV diagnoses and other categories that individuals living with the condition should be aware of:
If you have been taking Truvada as a means to treat your HIV condition and have begun to suffer from bone or kidney-related issues, do NOT hesitate to contact the New Jersey Truvada lawsuit lawyers of Onder Law Firm for a FREE consultation.
There are a number of demographic groups who have been most affected by HIV/AIDs in New Jersey. These populations include:
It is important to note these populations as they are likely to include individuals who have a higher likelihood of being prescribed or taking Truvada and thus being affected by its side effects.
Contact our New Jersey Truvada lawsuit lawyers at (314) 310-7924 to set up your FREE legal consultation.
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